Lerner Y*, Sukumaran S*, Chua MS, So SK, Qvit N (2022). Using field-effect biosensing technology to measure protein-protein interactions between molecular chaperone Hsp90 and protein kinase Cdc37. Journal of Visualized Experiments,181, e63495, 1-26. *Equal contribution .
Qvit N,Lin AJ, Elezaby A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D (2022). Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) Contributes to Ischemia-Reperfusion Injury. Pharmaceuticals, 15, 271. doi: 10.3390/ph15030271.
2021
Qvit N, ‘Peptides and peptidomimetics as foundations for drug discovery’ in ‘Encyclopedia of Molecular Pharmacology’, Springer Academic Press, 2021, Editors: Stefan Offermanns, Walter Rosenthal . doi.org/10.1007/978-3-030-57401-7, Switzerland.
2020
Azulay H, Leshem (Pellach) M, Qvit N (2020). Approach for comparing protein structures and origami models – Part 2. Multi-domain proteins. Biochimica et Biophysica Acta – Biomembranes, 1862, 183411. doi: 10.1016/j.bbamem.2020.183411.
Azulay H, Lutaty A, Qvit N (2020). Approach for comparing protein structures and origami models. Biochimica et Biophysica Acta – Biomembranes, 1862, 183132. doi: 10.1016/j.bbamem.2019.183132.
Rubin S, Qvit N (2020). Engineering antimicrobial peptides and other peptides to modulate protein-protein interactions in cancer. Current Topics in Medicinal Chemistry, 20, 1-14. doi: 10.2174/1568026620666201021141401.
Lerner Y, Hanout W, Gani S, Ben-Uliel S, Leshem (Pellach) M, Qvit N (2020). Natriuretic peptides as the basis of peptide drug discovery for cardiovascular diseases. Current Topics in Medicinal Chemistry, 20, 2904-2921. doi: 10.2174/1568026620666201013154326.
2019
Azulay H, Lutaty A, Qvit N (2019) Approach for comparing protein structures and origami models. Biochimica et Biophysica Acta – Biomembranes, accepted for publication.
Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D (2019). SAMβA, a selective antagonist of mitofusin 1-βIIPKC association, improves heart failure outcome in rats. Nature communication, 18;10(1):329.
2018
Kornfeld OS, Qvit N, Haileselassie B, Shamloo M, Bernardi P, Mochly-Rosen D (2018). Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo. Scientific Reports, 8(1), 14034.
Rubin S * , Tal-Gan Y, Gilon C, Qvit N *,# (2018). Conversion of protein active regions into peptidomimetic therapeutic leads using backbone cyclization and cycloscan – do it yourself. Current Topics in Medicinal Chemistry, 18, 601-610. * Equal contribution, # Corresponding author.
Rubin S * , Qvit N *,# (2018). Backbone-cyclized peptides: A critical review. Current Topics in Medicinal Chemistry, 18, 526-555. * Equal contribution, # Corresponding author.
2017
Cunningham AD*, Qvit N*,# Mochly-Rosen D# (2017). Peptides and Peptidomimetics as Regulators of Protein-Protein Interactions. Current Opinion in Structural Biology, 44, 59-66. *Equal contribution, #Corresponding authors.
Qvit N#, Rubin S, Urban TJ, Mochly-Rosen D, Gross RE (2017). Peptidomimetic Therapeutics: Scientific Approaches and Opportunities. Drug Discovery Today, 22, (2), 454-462. #Corresponding author.
Heymann HM, Wu Y, Lu Y, Qvit N, Gross GJ, Gross ER (2017). Transient receptor potential vanilloid 1 inhibitors block laparotomy- and opioid-induced infarct size reduction in rats. British Journal of Pharmacology, 174(24), 4826-4835.
Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW (2016). Correcting Mitochondrial Fusion Defects by Manipulating Mitofusin Conformation.Nature, 1, 540(7631), 74-79.
Qvit N, Disatnik MH, Jie S, Mochly-Rosen D (2016). Selective Phosphorylation Inhibitor of δPKC-PDK Protein-Protein Interactions; Application for Myocardial Injury in Vivo. Journal of the American Chemical Society, 22, 138(24), 7626-7635.
Hurt MC, Lu Y, Stary C, Piplani H, Small AB, Urban JT, Qvit N, Gross JG, Mochly-Rosen D, Gross RE (2016). Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial 2 Membrane Potential and Myocardial Reperfusion Injury. Journal of the American Heart Association, 26, 5(9), e003774, 1-13.
Qvit N#, Joshi AU, Cunningham AD, Ferreira CBJ, Mochly-Rosen D# (2016). GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Protein-Protein Interaction Inhibitor Reveals a Non-Catalytic Role for GAPDH Oligomerization in Cell Death. Journal of Biological Chemistry, 24, 291(26), 13608-13621. #Corresponding authors.
Qvit N#, Schechtman D, Pena DA, Berti DA, Soares CO, Miao Q, Liang AL, Baron LA, Teh-Poot C, Martínez-Vega P, Remirez-Sierra MJ, Churchill E, Cunningham AD, Malkovskiy AV, Federspiel NA, Gozzo FC, Torrecilhas AC, Alves MJM, Jardim A, Momar N, Dumonteil E, Mochly-Rosen D (2016). Scaffold Proteins LACK and TRACK as Potential Drug Targets in Kinetoplastid Parasites: Development of Inhibitors. International Journal for Parasitology: Drugs and Drug Resistance, 6, 74-84. #Corresponding author.
Qvit N#, Kornfeld OS (2016). Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation.Journal of Visualized Experiments, 107, e53589, 1-14. #Corresponding author.
Cunningham AD*, Qvit N*,# (2016). Specific Kinase Inhibition Using Peptides to Target Kinase-Substrate Docking. Chimica Oggi/Chemistry Today, 34(5), 16, 22-25. *Equal contribution, #Corresponding author.
Rubin S*, Qvit N*,# (2016).Cyclic Peptides for Protein-Protein Interaction Targets: Applications to Human Disease. Critical Reviews in Eukaryotic Gene Expression, 26(3), 199-221. *Equal contribution, #Corresponding author.
2015
Kornfeld OS, Hwang S, Disatnik MH, Chen CH, Qvit N, Mochly-Rosen D (2015). Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases. Circulation Research, 116(11), 1783-1799.
2014
Qvit N# (2014). Microwave Assisted Synthesis of Cyclic Phosphopeptides on Solid Support. Chemical Biology and Drug Design, 85(3), 300-305. #Corresponding author.
Qvit N#, Crapster JA (2014). Peptides that Target Protein-Protein Interactions as an Anti-Parasite Strategy. Chimica Oggi/Chemistry Today, 32(6), 62-66. #Corresponding author.
Qvit N, Mochly-Rosen D (2014). The Many Hats of Delta Protein Kinase C; One Enzyme with Many Functions. Biochemical Society Transactions, 42(6), 1529-1533.
Qvit N,Disatnik MH, Mochly-Rosen D (2014). Engineering a Delta Protein Kinase C Inhibitor that Selectively Inhibits Interaction and Phosphorylation of One Substrate of the Multi-Substrate Kinase. The FASEB Journal, 28, 1.
2013
Qi X*, Qvit N*, Su YC, Mochly-Rosen D (2013). A Novel Drp1 Inhibitor Diminishes Aberrant Mitochondrial Fission and Neurotoxicity.Journal of Cell Science, 126(Pt 3), 789-802. *Equal contribution.
2012
Qvit N, Disatnik MH, Mochly-Rosen D (2012). Novel Selective Peptide Regulator of Protein Kinase C Based on Rational Approach Design. Biosensors and Bioelectronics, 2, 142.
2011
Qvit N# (2011).Development and Therapeutics Applications of Oligonucleotides and Peptides. Chimica Oggi/Chemistry Today, 29(2), 16, 4-7. #Corresponding author.
2010
Qvit N, Mochly-Rosen D (2010). Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure. Drug Discovery Today: Disease Mechanisms, 7(2), e87-e93.
Mochly-Rosen D, Qvit N (2010). Peptide Inhibitors of Protein-Protein Interactions: From Rational Design to the Clinic. Chimica Oggi/Chemistry Today, 28(1), 14-16.
2009
Qvit N, Hatzubai A, Shalev ED, Ben-Neriah Y, Gilon C (2009). Design and Synthesis of Backbone Cyclic Phosphorylated Peptides: The I Kappa B Model. Biopolymers, 91(2), 157-168.
Churchill E*, Qvit N*, Mochly-Rosen D (2009). Rationally Designed Peptide Regulators of Protein Kinase C. Trends in Endocrinology and Metabolism, 20(1), 25-33. *Equal contribution.
Qvit N, Disatnik MH, Mochly-Rosen D (2009). Peptide Regulators of Protein-Protein Interactions with Selectivity for Specific Sub-Cellular Compartments. Biopolymers, 92, 322.
Qvit N, Hatzubai A, Shalev ED, Ben-Neriah Y, Gilon C (2009). Design and Synthesis of Backbone Cyclic Phosphopeptides: The IκB Model. Advances in Experimental Medicine and Biology, 611, 139-140.
2008
Qvit N#, Monderer-Rothkoff G, Ido A, Shalev ED, Amster-Choder O, Gilon C# (2008). Development of Bifunctional Photoactivatable Benzophenone Probes and their Application to Glycoside Substrates. Biopolymers, 90(4), 526-536. #Corresponding authors.
Qvit N, Reuveni H, Gazal S, Zundelevich A, Blum G, Niv YM, Feldstein A, Meushar S, Shalev ED, Friedler A, Gilon C (2008). Synthesis of Novel Macrocyclic Library: Discovery of an IGF-1R Inhibitor. Journal of Combinatorial Chemistry, 10(2), 256-266.
Nuti F, Qvit N, Rizzolo F, Hurevich M, Carotenuto A, Peroni E, Chelli M, Rovero P, Gilon C, Papini AM (2008). Microwave-Assisted Solid Phase Synthesis of Backbone Cyclic Glycopeptide Libraries. Journal of Peptide Science, 14, 131.
2007
Qvit N, Barda Y, Shalev ED, Gilon C (2007). A Laboratory Preparation of Aspartame Analogs Using Simultaneous Multiple Parallel Synthesis Methodology. Journal of Chemical Education, 84(12), 1988-1991.
2006
Qvit N, Gilon C, Amster-Choder O, Monderer-Rothkoff G (2006). Using Novel Benzophenon-Glucosides to Study Microbial Sugar Recognition and Translocation by Photo-Affinity Labeling. Journal of Peptide Science, 12, 84.
2004
Qvit N, Reuveni H, Gazal S, Peretzman-Shemer A, Blum G, Niv YM, Feldstein A, Meushar S, Gilon C (2004). Novel Macrocyclic Libraries with Spatial Diversity (SIBs): Application for the Discovery of IGF-1R Inhibitor. Journal of Peptide Science, 10, 95.
